Not scientific by any means, but perhaps a couple of mileage examples from personal experience are worth mentioning....
Number 1: Current '02 GMC Sierra (1/2 ton extended cab short bed, 220k miles, 5.3 V8, cab high camper shell, factory tow pkg, Belltech lowering kit), tow vehicle for our 2307C. When towing, we average about 14-15 mpg on level highways at 60-65 mph - about 2-4 mpg less than without the trailer. Camper shell was on the truck when purchased so no experience towing without it - suspect removing the shell would impact the "stagnation zone" Jack describes between the truck and trailer, increasing turbulence and the effective "flat plate" area of he trailer, with some resulting decrease in mileage.
Number 2: Years ago '79 Chevy Suburban (1/2 ton, 140k miles, 350 V8, 4 speed granny low manual trans) - daily driver, 60 miles per day freeway commute. Installed a Belltech lowering kit, front air dam and smaller mirrors about a year after purchasing the truck used - average freeway mileage went up from around 14-15 mpg to 18-19. With no other changes made, the only factor that would account for the improvement in fuel economy is drag reduction (never bought the trailer we intended to tow with the Suburban, so have no towing / non-towing mileage comparison).