The short answer is that for the type of travel you have planned, a Hi-Lo will do fine.
Now for the longer answer: Compared with other trailers, all other factors the same, with the low profile and low center of gravity, Hi-Lo's do tow like a dream. Sail effect is minimal. Tow vehicle gas mileage is better. They are heavier than comparably sized trailers, so you'll want to make sure your tow vehicle can handle extended 6 and 7% grades (in the west). My Hi-Lo's have proven to be very rugged, probably due to the steel and aluminum frames and minimal frame flexing that goes along with the low profile and split construction.
Camping is somewhat different in the west in that, once you get away from the Interstates, there are fewer full-hookup facilities and many more dry camps. Furthermore, many prime campgrounds are set in the mountains. Access can be more challenging, and a Hi-Lo is good at this because of the low profile, however camp set up can be more difficult because finding a level enough campsite (for a Hi-lo), or getting the Hi-Lo level enough to raise, is not always easy.
Other than the frame and telescoping feature, Hi-Lo trailers are pretty much like other brands... fresh water, gray water, black water systems, electrical systems, etc., all these can have occasional problems, and typically, are road repairable. The axiom that "the more complicated a machine is, the more there is that can go wrong," also applies to Hi-Lo trailers. Although very reliable, there is always the potential for lift system problems, and if traveling in the west, it won't be easy to find a Hi-Lo dealer to take care of these. Out here, VERY few other trailer dealers have ever seen a Hi-Lo, and generally I wouldn't trust them to even adjust my cables. So learn your Hi-Lo and be prepared to diagnose and make repairs if the rare happens and you have a lift issue. Do you need to carry a spare set of lift cables... no, should you be capable of setting a cable back onto a pulley... yes.
Finally, regarding comfort, if you've never done it before, sharing one small room for months at a time can be interesting. Intimacy and love aside, its nice to occasionally have some space. My wife and I finally went to a longer trailer, with a bed set up all the time, so one of us could read/puzzle/watch a DVD, without feeling we were disturbing the other trying to sleep. Something to consider when looking at the 22 footer.
Hope this helps!